The Synagogue of Siena, located a few steps from Piazza del Campo, was designed by architect Zanobi del Rosso. Inaugurated in 1786, the building is one of the few examples of Rococo and Neoclassical architecture in the area.

The facade, simple and unadorned, contrasts with the elegant and richly decorated interior. Still used by the local Jewish community, the synagogue houses ancient silverware and ritual vestments and offers the possibility to visit the suggestive ancient women's gallery, which is now used for temporary exhibitions and educational activities.